Heil Lab of evolutionary genetics

McNeill, J., N. Brandt, E.J. Schwarzkopf, M. Jimenez Gallardo, C. Smukowski Heil. Temperature affects recombination rate plasticity and meiotic success between thermotolerant and cold tolerant yeast species. bioRxiv https://doi.org/10.1101/2024.08.28.610152

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Bursell, M.,  M. Rohilla, L. Ramirez, Y. Cheng, E.J. Schwarzkopf, R.F. Guerrero, C. Smukowski Heil.     
Mixed outcomes in recombination rates after domestication: Revisiting theory and data. bioRxiv https://doi.org/10.1101/2024.08.07.607048

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Schwarzkopf, E. J., N. Brandt, C. Smukowski Heil. The recombination landscape of introgression in yeast. bioRxiv https://doi.org/10.1101/2024.01.04.574263

 

Smukowski Heil, C. 2023. Loss of heterozygosity and its importance in evolution. Journal of Molecular Evolution. https://doi.org/10.1007/s00239-022-10088-8

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Madden, A.A., C. Lahue, C.L. Gordy, J.L. Little, L.M. Nichols, M.D. Calvert, R.R. Dunn, C. Smukowski Heil. 2021. Sugar-seeking insects as a source of diverse bread-making yeasts with enhanced attributes. Yeast. 

https://doi.org/10.1002/yea.3676

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Smukowski Heil, C., K. Patterson, A.S. Hickey, E. Alcantara, M.J. Dunham. 2021. Transposable Element Mobilization in Interspecific Yeast Hybrids. Genome Biology and Evolution 13(3).  https://doi.org/10.1093/gbe/evab033

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Lahue, C., A.A. Madden, R.R. Dunn, C. Smukowski Heil. 2020. History and Domestication of Saccharomyces cerevisiae in Bread Baking. Frontiers in Genetics, 11, 584718. https://doi.org/10.3389/fgene.2020.584718

              See our video on this topic, a part of the NCSU Applied Ecology Fermentology series!

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Smukowski Heil, C., C.R.L. Large, K. Patterson, A.S. Hickey, C.C. Yeh, M.J. Dunham. 2019. Temperature preference can bias parental genome retention during hybrid evolution. PLoS Genetics 15(9): e1008383. doi: https://doi.org/10.1371/journal.pgen.1008383

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Lancaster, S.M., C. Payen, C. Smukowski Heil, M.J. Dunham. 2019. Fitness benefits of loss of heterozygosity in Saccharomyces hybrids. Genome Research 29: 1685-1692. https://doi.org/10.1101/gr.245605.118

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Smukowski Heil, C.S.*, J.N. Burton*, I. Liachko*, A. Friedrich, N.A. Hanson, C.L. Morris, J. Schacherer, J. Shendure, J.H. Thomas, M.J. Dunham. 2017. Identification of a novel interspecific hybrid yeast from a metagenomic open fermentation sample using Hi-C. Yeast. https://doi.org/10.1002/yea.3280

*co-first authors

Press coverage: Science, ScienceNews, ABC Radio Sydney

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Hope E.A., C.J. Amorosi, A.W. Miller, K. Dang, C.S. Smukowski Heil, M.J. Dunham. 2017. Experimental evolution reveals favored adaptive routes to cell aggregation in yeast. Genetics 206 (2):1153-1167.

https://doi.org/10.1534/genetics.116.198895

Press coverage: This Week in Evolution podcast, Saccharomyces Genome Database

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Smukowski Heil, C.S., C.G. DeSevo, D.A. Pai, C.M. Tucker, M.L. Hoang, M.J. Dunham. 2017. Loss of heterozygosity drives adaptation in hybrid yeast. Molecular Biology and Evolution 34 (7):1596-1612. https://doi.org/10.1093/molbev/msx098

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Smukowski Heil, C.S., C. Ellison, M. Dubin, and M.A.F. Noor. 2015. Recombining without hotspots: A comprehensive evolutionary portrait of recombination in two closely related species of Drosophila. Genome Biology and Evolution.  

https://doi.org/10.1093/gbe/evv182

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Smukowski Heil, C.S. 2014. No detectable effect of the DNA methyltransferase DNMT2 on Drosophila meiotic recombination. G3: Genes, Genomes, Genetics, 4 (11): 2095-2100.

https://doi.org/10.1534/g3.114.012393

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Heil, C. S. S., B. Manzano-Winkler, M. J. Hunter, J. K. F. Noor, and M. A. F. Noor. 2013. Witnessing Evolution First-hand: A K-12 Laboratory Exercise in Genetics and Evolution Using Drosophila. American Biology Teacher, 75: 116-119.

https://doi.org/10.1525/abt.2013.75.2.8

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Heil, C. S. S., M. J. Hunter, J. K. F. Noor, K. Miglia, B. Manzano-Winkler, S. R. McDermott, and M. A. F. Noor. 2012. Witnessing phenotypic and molecular evolution in the fruit fly. Evolution: Education and Outreach, 5: 629-634.

https://doi.org/10.1007/s12052-012-0447-5

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Heil, C. S. S., and M. A. F. Noor. 2012. Zinc finger binding motifs do not explain recombination variation within or between species of Drosophila. PLoS One, 7: e45055.

https://doi.org/10.1371/journal.pone.0045055

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McGaugh, S. E., C. S. S. Heil, B. Manzano-Winkler, L. Loewe, S. Goldstein, T. L. Himmel, M. A. F. Noor. 2012. Recombination modulates how selection affects linked sites in Drosophila. PLoS Biology, 10: e1001423.

https://doi.org/10.1371/journal.pbio.1001422

PLoS Biology Synopsis: Mejia R (2012) Natural Selection, Not Mutation: Recombination in Drosophila Increases Diversity. PLoS Biol 10(11): e1001423. doi:10.1371/journal.pbio.1001423

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Smukowski, C. S., and MAF Noor (2011). Recombination rate variation in closely related species. Heredity 107(6): 496-508.

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