Heil Lab of evolutionary genetics

Schwarzkopf, E. J., N. Brandt, C. Smukowski Heil. The recombination landscape of introgression in yeast. bioRxiv https://doi.org/10.1101/2024.01.04.574263

 

Smukowski Heil, C. 2023. Loss of heterozygosity and its importance in evolution. Journal of Molecular Evolution. https://doi.org/10.1007/s00239-022-10088-8

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Madden, A.A., C. Lahue, C.L. Gordy, J.L. Little, L.M. Nichols, M.D. Calvert, R.R. Dunn, C. Smukowski Heil. 2021. Sugar-seeking insects as a source of diverse bread-making yeasts with enhanced attributes. Yeast. 

https://doi.org/10.1002/yea.3676

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Smukowski Heil, C., K. Patterson, A.S. Hickey, E. Alcantara, M.J. Dunham. 2021. Transposable Element Mobilization in Interspecific Yeast Hybrids. Genome Biology and Evolution 13(3).  https://doi.org/10.1093/gbe/evab033

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Lahue, C., A.A. Madden, R.R. Dunn, C. Smukowski Heil. 2020. History and Domestication of Saccharomyces cerevisiae in Bread Baking. Frontiers in Genetics, 11, 584718. https://doi.org/10.3389/fgene.2020.584718

              See our video on this topic, a part of the NCSU Applied Ecology Fermentology series!

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Smukowski Heil, C., C.R.L. Large, K. Patterson, A.S. Hickey, C.C. Yeh, M.J. Dunham. 2019. Temperature preference can bias parental genome retention during hybrid evolution. PLoS Genetics 15(9): e1008383. doi: https://doi.org/10.1371/journal.pgen.1008383

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Lancaster, S.M., C. Payen, C. Smukowski Heil, M.J. Dunham. 2019. Fitness benefits of loss of heterozygosity in Saccharomyces hybrids. Genome Research 29: 1685-1692. https://doi.org/10.1101/gr.245605.118

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Smukowski Heil, C.S.*, J.N. Burton*, I. Liachko*, A. Friedrich, N.A. Hanson, C.L. Morris, J. Schacherer, J. Shendure, J.H. Thomas, M.J. Dunham. 2017. Identification of a novel interspecific hybrid yeast from a metagenomic open fermentation sample using Hi-C. Yeast. https://doi.org/10.1002/yea.3280

*co-first authors

Press coverage: Science, ScienceNews, ABC Radio Sydney

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Hope E.A., C.J. Amorosi, A.W. Miller, K. Dang, C.S. Smukowski Heil, M.J. Dunham. 2017. Experimental evolution reveals favored adaptive routes to cell aggregation in yeast. Genetics 206 (2):1153-1167.

https://doi.org/10.1534/genetics.116.198895

Press coverage: This Week in Evolution podcast, Saccharomyces Genome Database

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Smukowski Heil, C.S., C.G. DeSevo, D.A. Pai, C.M. Tucker, M.L. Hoang, M.J. Dunham. 2017. Loss of heterozygosity drives adaptation in hybrid yeast. Molecular Biology and Evolution 34 (7):1596-1612. https://doi.org/10.1093/molbev/msx098

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Smukowski Heil, C.S., C. Ellison, M. Dubin, and M.A.F. Noor. 2015. Recombining without hotspots: A comprehensive evolutionary portrait of recombination in two closely related species of Drosophila. Genome Biology and Evolution.  

https://doi.org/10.1093/gbe/evv182

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Smukowski Heil, C.S. 2014. No detectable effect of the DNA methyltransferase DNMT2 on Drosophila meiotic recombination. G3: Genes, Genomes, Genetics, 4 (11): 2095-2100.

https://doi.org/10.1534/g3.114.012393

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Heil, C. S. S., B. Manzano-Winkler, M. J. Hunter, J. K. F. Noor, and M. A. F. Noor. 2013. Witnessing Evolution First-hand: A K-12 Laboratory Exercise in Genetics and Evolution Using Drosophila. American Biology Teacher, 75: 116-119.

https://doi.org/10.1525/abt.2013.75.2.8

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Heil, C. S. S., M. J. Hunter, J. K. F. Noor, K. Miglia, B. Manzano-Winkler, S. R. McDermott, and M. A. F. Noor. 2012. Witnessing phenotypic and molecular evolution in the fruit fly. Evolution: Education and Outreach, 5: 629-634.

https://doi.org/10.1007/s12052-012-0447-5

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Heil, C. S. S., and M. A. F. Noor. 2012. Zinc finger binding motifs do not explain recombination variation within or between species of Drosophila. PLoS One, 7: e45055.

https://doi.org/10.1371/journal.pone.0045055

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McGaugh, S. E., C. S. S. Heil, B. Manzano-Winkler, L. Loewe, S. Goldstein, T. L. Himmel, M. A. F. Noor. 2012. Recombination modulates how selection affects linked sites in Drosophila. PLoS Biology, 10: e1001423.

https://doi.org/10.1371/journal.pbio.1001422

PLoS Biology Synopsis: Mejia R (2012) Natural Selection, Not Mutation: Recombination in Drosophila Increases Diversity. PLoS Biol 10(11): e1001423. doi:10.1371/journal.pbio.1001423

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Smukowski, C. S., and MAF Noor (2011). Recombination rate variation in closely related species. Heredity 107(6): 496-508.

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